Formulasi dan Uji Mutu Fisik Sediaan Pasta Gigi Ekstrak Biji Jintan Hitam (Nigella sativa)

Formulation and Physical Quality Test of Toothpaste from Black Cumin Seeds (Nigella sativa)

  • Vika Novia Agustyani Program Pendidikan Diploma Farmasi, Akademi Farmasi Mitra Sehat Mandiri Sidoarjo
  • Cikra Ikhda Nur Hamida Safitri Program Pendidikan Diploma Farmasi, Akademi Farmasi Mitra Sehat Mandiri Sidoarjo

Abstract

Black Cumin seeds (Nigella sativa) have antibacterial activity because they contain thymoquinones, tannins, saponanins, and flavonoids. According to (Sinaga, 2018) black cumin seeds can inhibit the Streptococcous mutans bacteria that causes dental caries. The research conducted was experimental. The thick extract of black cumin seeds (Nigella sativa) is formulated into toothpaste by varying the concentration of the viscous extract of black cumin seeds (Nigella sativa). The concentration of the active substance used was 0% in the control formula, 2% in formula I, 4% in formula II, 6% in formulation III. Then performed a physical stability test of the toothpaste preparation consisting of homogeneity, pH, high foam, dispersibility, color, odor, and taste. The test was carried out for 28 days of storage. During 28 days of storage all formulations were stable, homogeneity, pH and high foam preparation were stable and met the standards. The particles are evenly distributed so that the preparation has a stable color, smell and taste. The thick extract of black cumin seeds (Nigella sativa) can be formulated into a toothpaste preparation that is stable and meets the requirements. The most stable formulation is formulation I with a concentration of 2% viscous black cumin seed (Nigella sativa) extract.

References

[1] Fakultas Kedokteran UI. 2001. Kapita Selekta Kedokteran. Edisi Ketiga. Jilid 1. Media Aesculapius, Fakultas Kedokteran Universitas Indonesia, Jakarta. Hal.500-505.
[2] Rizka K, 2016. Pengaruh konsentrasi Ekstrak Etanol Daun Mangga Arumanis Muda Mangifera indica L.) Terhadap Hambatan Pertubuhan Bateri Streptococus mutans in vitro. Universitas Muhammadiyah. Surakarta.
[3] Oktovia DH, 2017. Uji Aktivitas Bateri Menggunakan Metode Cakram Disk. Politeknik Kesehatan Kementrian Kesehatan Banjarmasin. Banjarmasin.
[4] ktovia DH, 2017. Uji Aktivitas Bateri Menggunakan Metode Cakram Disk. Politeknik Kesehatan Kementrian Kesehatan Banjarmasin. Banjarmasin
[5] Grossman, L.L., Oliet, S., dan Rio, C.E.D. 1995. Ilmu Endodontik dalam Praktek.
[6] Pistorius, A., Willershausen, B., Steinmeier, EM., & Kreisler, M. (2003). Efficacy of subgingival irrigation using herbal exract on gingival inflammation. J Periodontol. 74 : 616-22.
[7] Farlina Ina 2006, Uji Aktvitas Antibakteri Beberapa Formula Pasta Gigi Ekstrak Etanol Jintan Hitam (Nigella sativa) Terhadap Streptococus mutans, Makassar.
[8] Farlina Ina 2006, Uji Aktvitas Antibakteri Beberapa Formula Pasta Gigi Ekstrak Etanol Jintan Hitam (Nigella sativa) Terhadap Streptococus mutans, Makassar.
[9] Saputri, G.A.Y., Chusniasih, D., Putri E.K. 2020. Formulasi Pasta Gigi Ekstrak Daun Salam (Syzygiumpolyanthawihght) Sebagai Penghambat Pertumbuhan Streptococcus mutans, Jurnal Farmasi Malahayati, Vol. 3 No. 1: 66-78.
[10] Departemen Kesehatan RI. 1995. Materia Medika Indonesia Jilid IV. Direktorat Jenderal Pengawasan Obat dan Makanan : Jakarta.
[11] Agustiningsih, 2010. Optimasi Cairan Penyari Pada Pembuatan Eksrak Pandan Wangi (Pandanus amaryllifous Roxb) Secara Maserasi Terhadap Kadar Fenolik dan Flavonoid Total, Momentum, Vol. 6 No. 2: 36-41
[12] Departemen Kesehatan RI. 2017. Farmakope Herbal Indonesia. Direktorat Jenderal Kefarmasian dan Alat Kesehatan : Jakarta.
[13] Mawarni, A. 2014. Aktivitas Antibakteri Minyak Atsiri Rimpang Temu Putih (Curcuma zedoaria (Berg.) Roscoe) Dan Kulit Kayu Lawang Terhadap Bakteri Staphylococcus aureus dan Pseudomonas aeruginosa Sensitif Dan Multiresisten . Fakultas Farmasi. Universitas Muhammadiyah Surakarta. Surakarta.
Published
2021-04-10
How to Cite
Agustyani, V. N., & Safitri, C. I. N. H. (2021). Formulasi dan Uji Mutu Fisik Sediaan Pasta Gigi Ekstrak Biji Jintan Hitam (Nigella sativa). Proceeding of Mulawarman Pharmaceuticals Conferences, 13(1), 232-238. https://doi.org/10.25026/mpc.v13i1.472