Kajian In Silico Senyawa Turunan Kalkon sebagai Antikanker
Abstract
Senyawa kalkon termasuk dalam famili flavonoid yang memiliki aktivitas seperti antimalarial, antioksidan, antimikroba, antikanker dan analgesik. Aktivitas antikanker senyawa kalkon berbasis 3,4-metilendioksi asetofenon di analisis melalui metode docking dengan adanya interaksi antara senyawa turunan kalkon dengan enzim topoisomerase II. Senyawa turunan kalkon berbasis 3,4-metilendioksi asetofenon dioptimasi dengan Hyperchem 8.0 dan di docking dengan MOE Chemical Computing Group. Interaksi antara senyawa turunan kalkon dengan enzim topoisomerase II berupa interaksi hidrogen dan arene hydrogen.
References
[1] WHO (diakses 06 November 2018). Cancer. http://www.who.int/cancer/en/
[2] Rahman, M. 2011. Chalcone : A Valueable Insight Into The Recent Advances And Potential Pharmacological Activities. Chemical Science Journal.
[3] Pingaew, R, et al. 2014. Synthesis, Biological Evaluation and Molecular Docking of Novel Chalcone-Coumarin Hybrids as Anticancer and Antimalarial Agents. European Journal of Medicinal Chemistry, 65-76.
[4] Prada-Gracia D. et al. 2016. Application of Computational Methods for Anticancer Drug Discovery, Design, and Optimization. Bol Med Hosp Infant Mex. http://dx.doi.org/10.1016/j.bmhimx.2016.10.006
[5] Jandial, Danielle D. Et al. 2014. Molecular Targeted Approaches To Cancer Therapy And Prevention Using Chalcones. Curr Cancer Drug Targets 14(2).
[6] Nath Dhar, Durga. 1981. The Chemistry of Chalcones and Related Compounds. SERBIULA (sistema Librum 2.0).
[7] Nitiss, J. L. 2009. Targetting DNA Topoisomerase II in Cancer Chemotherapy. Nature Reviews Cancer, 338-350.
[8] Cole JC, et al. 2005. Comparing protein-ligand docking programs is difficult. Proteins. Aug 15;60(3):325-32. Review. PubMed PMID: 15937897.
[9] Jadhav, Ahwini K, and Mohan Karupayyil. 2017. Molecular Docking Studies On Thirteen Fluoroquinolones With Human Topoisomerase II A And B. In Silico Pharmacology 5:4. Germany.
[10] Nasution, Mochammad, et al. 2016. Chalcone and Its Pyrazole Derivatives as Potential Plasmodium falciparum Lactate Dehydrogenase Inhibitor: In Silico Approach for New Antimalarial Drug. DOI:10.13140/RG.2.1.2887.3847.
[2] Rahman, M. 2011. Chalcone : A Valueable Insight Into The Recent Advances And Potential Pharmacological Activities. Chemical Science Journal.
[3] Pingaew, R, et al. 2014. Synthesis, Biological Evaluation and Molecular Docking of Novel Chalcone-Coumarin Hybrids as Anticancer and Antimalarial Agents. European Journal of Medicinal Chemistry, 65-76.
[4] Prada-Gracia D. et al. 2016. Application of Computational Methods for Anticancer Drug Discovery, Design, and Optimization. Bol Med Hosp Infant Mex. http://dx.doi.org/10.1016/j.bmhimx.2016.10.006
[5] Jandial, Danielle D. Et al. 2014. Molecular Targeted Approaches To Cancer Therapy And Prevention Using Chalcones. Curr Cancer Drug Targets 14(2).
[6] Nath Dhar, Durga. 1981. The Chemistry of Chalcones and Related Compounds. SERBIULA (sistema Librum 2.0).
[7] Nitiss, J. L. 2009. Targetting DNA Topoisomerase II in Cancer Chemotherapy. Nature Reviews Cancer, 338-350.
[8] Cole JC, et al. 2005. Comparing protein-ligand docking programs is difficult. Proteins. Aug 15;60(3):325-32. Review. PubMed PMID: 15937897.
[9] Jadhav, Ahwini K, and Mohan Karupayyil. 2017. Molecular Docking Studies On Thirteen Fluoroquinolones With Human Topoisomerase II A And B. In Silico Pharmacology 5:4. Germany.
[10] Nasution, Mochammad, et al. 2016. Chalcone and Its Pyrazole Derivatives as Potential Plasmodium falciparum Lactate Dehydrogenase Inhibitor: In Silico Approach for New Antimalarial Drug. DOI:10.13140/RG.2.1.2887.3847.
Published
2019-04-30
How to Cite
Oktaviani, R., Arifian, H., Rahmadani, A., Zamruddin, N. M., & Rusli, R. (2019). Kajian In Silico Senyawa Turunan Kalkon sebagai Antikanker. Proceeding of Mulawarman Pharmaceuticals Conferences, 9(1), 22-26. https://doi.org/10.25026/mpc.v9i1.309
Section
Articles
