Kajian In Silico Senyawa Turunan Kalkon sebagai Antikanker

  • Riska Oktaviani
  • Hanggara Arifian
  • Agung Rahmadani
  • Nur Masyithah Zamruddin
  • Rolan Rusli Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Kalimantan Timur, Indonesia http://orcid.org/0000-0003-1264-5933

Abstract

Senyawa kalkon termasuk dalam famili flavonoid yang memiliki aktivitas seperti antimalarial, antioksidan, antimikroba, antikanker dan analgesik. Aktivitas antikanker senyawa kalkon berbasis 3,4-metilendioksi asetofenon di analisis melalui metode docking dengan adanya interaksi antara senyawa turunan kalkon dengan enzim topoisomerase II. Senyawa turunan kalkon berbasis 3,4-metilendioksi asetofenon dioptimasi dengan Hyperchem 8.0 dan di docking dengan MOE Chemical Computing Group. Interaksi antara senyawa turunan kalkon dengan enzim topoisomerase II berupa interaksi hidrogen dan arene hydrogen.

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Published
2019-04-30
How to Cite
Oktaviani, R., Arifian, H., Rahmadani, A., Zamruddin, N. M., & Rusli, R. (2019). Kajian In Silico Senyawa Turunan Kalkon sebagai Antikanker. Proceeding of Mulawarman Pharmaceuticals Conferences, 9(1), 22-26. https://doi.org/10.25026/mpc.v9i1.309

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