Potensi Sari Kurma (Phoenix dactylifera) sebagai Peluruh Kristal Kalsium Oksalat Secara In Vitro

  • Wilujeng Ayu Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Kalimantan Timur, Indonesia
  • Wisnu Cahyo Prabowo Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Kalimantan Timur, Indonesia
  • Niken Indriyanti Laboratorium Penelitian dan Pengembangan Kefarmasian "Farmaka Tropis", Fakultas Farmasi, Universitas Mulawarman, Samarinda, Kalimantan Timur, Indonesia

Abstract

Dates (Phoenix dactilyfera) contain chemical compositions that can be used as traditional medicine for Calcium oxalate of kidney stone decay. Compound in palm juice can make Calcium oxalate dissolving is flavonoid and calium . The purpose of this study was to determine the effect of Palm dates juice dissolving calcium oxalate to determine the relationship between the concentration of dates palm juice with calcium solubility in kidney stones. To test its activities carried out in vitro using calcium oxalate which incubated for 3 hours with shaken out every 20 minutes at 37oC Determination of the solubility of calcium in date palm juice is by weighs insoluble calcium oxalate. Palm's juice concentration is divided into 60%, 50%, 40%, 30% and 20%. The results of these concentrations can be concluded that the juice of dates has the activity of dissolving calcium oxalate from kidney stones with average result weight in sequence 0.02 + 0.005 g; 0.02 + 0.005 g; 0.03 + 0.005 g; 0.04 + 0.005 g and 0.05 + 0.005 g. Positive control (batugin elixir) 60%, 50%,40%, 30% and 20% with in sequence result 0.08 + 0.001 g; 0.08 + 0.001 g; 0.08 + 0.005 g; 0.09 + 0.005 g; and 0.1 + 0.005 g. Negative Control result 0.11 g. The results obtained from the standard deviation are 0.031. Calcium oxalate that is not dissolved at most in the sample is 20% with an average of 0.05 + 0.005 g and the positive control is 20% of the batugine with an average of 0.1 + 0.005 g.Based on the weighing of calcium oxalate from each concentration the higher the concentration will cause the least insoluble calcium oxalate.

References

[1] Pearce, C. Evelyn. 2002. Anatomi dan Fisiologi untuk Paramedis. Jakarta: Penerbit PT GramediaPustaka Utama

[2] Maryati. K., Azizahwati., Puswaningrum, Kadarsih., 2009, Aktivitas Sari Lobak (Raphanus sativus L) Terhadap Kelarutan Batu Ginjal Kalsium Secara In Vitro, Jurnal Penelitian, FMIPA UI, Jakarta

[3] Alelign, T., & Petros, B. 2018. Kidney Stone Disease: An Update on Current Concepts.Advances In Urology, 2018, 1-12

[4] Effendi, E. Mulyati dan Sri Wardatun. 2012. Potensi Sari Buah Semangka Merah (Citrullus vulgaris rubrum) dan Sari Buah Semangka Kuning (Citrullus vulgaris flavum) sebagai Peluruh Batu Ginjal Kalsium Oksalat secara In Vitro. Ekologia, Vol. 13 No. 1.

[5] Ratri, W. N. 2008. Uji KelarutanBatu Ginjal Kalsium dalam Fraksi Air dan Etil Asetat Daun Jagung (Zea mays L.) secara In Vitro dengan Metode Spektrofotometri Serapan Atom.Skripsi. Surakarta: Fakultas Farmasi Universitas Muhammadiyah

[6] Asnah, 2012. Pengaruh Pemberian Sari Buah Kurma (Phoenix dactylifera L.) terhadap Perubahan Jumlah Trombosit pada Tikus (Rattus novergicus). Majalah Farmasi dan Farmakologi. 16 (1): 85-88

[7] Abdelrahman, H.A. 2012. Protective effect of Dates (Phoenix dactylifera L.) and Licoricae (Glycoriza glabra) on Carbon Tetrachloridae-Induced Hepatotoxicity in Dogs. Global Veterinaria Journal. 9 (2)

[8] Houston, M., Harper, K. 2008. Potassium, magnesium, and calcium: Their role in both the cause and treatment of hypertension. The Journal of Clinical Hypertension,10(7). Juli,2015

[9] Rahardjo,Kristi Hari. 2003. Pengaruh Infusa Daun Pandan Wangi Terhadap Kelarutan Kalsium Batu Ginjal Secara In VitroMenggunakan Metode Spektrofotometri Serapan Atom. Sanata Dharma: Yogyakarta

[10] Indrianto. 2012. Pengaruh Ekstrak Daun Ciplukan Terhadap Kelarutan Batu Ginjal Kalsium Secara In Vitro.Prosiding Seminar Nasional Kimia Unesa. Program Keahlian Analisis Kimia Direktorat Program Diploma. IPB: Bandung

[11] Krisyanella., Dachriyanus., Marlina. 2011.Karakterisasi Simplisia Dan Ekstrak Serta Isolasi Senyawa AktifAntibakteri Dari Daun Karamunting( Rhodomyrtus tomentosa ( W.Ait ) Hassk ) (skripsi). Padang: Universitas Andalas.

[12] Syafitri, N. E., Bintang, M. and Falah, S. 2014.Kandungan Fitokimia, Total Fenol, dan Total Flavonoid Ekstrak Buah Herendong (Melastoma affine D. Don), Current Biochemistry,1(3), pp. 105?115.

[13] Ramadhani, N., Yuliet, Y., & Khaerati, K. 2018. Aktivitas Ekstrak Kulit Batang Langsat (Lansium Parasiticum (Osbeck) Sahni & Bennet) Terhadap Kelarutan Kalsium Batu Ginjal Secara In vitro. Biocelebes, 12(2

[14] Nadila F. 2014. Antihypertensive Potential Of Chayote Fruit Extract For Hypertension Treatment. J Majority 3(7): 34-38.

[15] Marliana SD, Suryanti V, dan Suyono. 2005. Skrining Fitokimia dan Analisis Kromatografi Lapis Tipis Komponen Kimia Buah Labu Siam (Sechium edule Jacq. Swartz.) dalam Ekstrak Etanol. FMIPA Universitas Sebelas Maret (UNS) Surakarta. Biofarmasi 3(1): 26-31

[16] Haryati, N.A., C.S. Erwin. 2015. Uji Toksisitas dan Aktivitas Antibakteri Ekstrak Daun Merah (Syzygium mytifolium Walp) terhadap Bakteri Staphylococus aureus dan Escherichia coli. J. Kimia Mulawarman,13(1): 35-39

[17] Suparjo. 2008. Saponin: Peran dan Pengaruhnya Bagi Ternak dan Manusia. Laboratorium Mahakam Ternak Fakultas Peternakan Universitas Jambi.

[18] Marliana, S.D., Saleh, C. 2011. Uji Fitokimia dan Aktivitas Antibakteri Ekstrak Kasar Etanol, Fraksi nHeksana, Etil asetat, dan Metanol dari Buah Labu Air (Lagenari Siceraria (Morliana). J. Kimia Mulawarman, 8(2): 39-63

[19] Ratri, W. N. (2008). Uji KelarutanBatu Ginjal Kalsium dalam Fraksi Air dan Etil Asetat Daun Jagung (Zea mays L.) secara In Vitro dengan Metode Spektrofotometri Serapan Atom.Skripsi. Surakarta: Fakultas Farmasi Universitas Muhammadiyah.
Published
2020-12-16
How to Cite
Ayu, W., Prabowo, W. C., & Indriyanti, N. (2020). Potensi Sari Kurma (Phoenix dactylifera) sebagai Peluruh Kristal Kalsium Oksalat Secara In Vitro. Proceeding of Mulawarman Pharmaceuticals Conferences, 12(1), 1-6. https://doi.org/10.25026/mpc.v12i1.400

Most read articles by the same author(s)