Upaya Pembuatan Cashew Nut Shell Liquid Sebagai Bahan Baku Produk Farmasi
Efforts to Make Cashew Nut Shell Liquid as Raw Material for Pharmaceutical Products
AbstractCashew (Anacardium occidentale L) is one of the plantation commodities which has a high economic value. However, the utilization is still limited to the cashew, while the shells have not been used as a product. The purpose of this study was to obtain cashew nut shell liquid (CNSL) oil from cashew nut shells. Furthermore, efforts were made to purify CNSL which could be used as an opportunity for the use of cashew nut shell oil in the pharmaceutical field. This research was conducted experimentally with the Soxhlet extraction method using n-hexane solvent and concentrated using a rotary evaporator. The analysis carried out included yield, viscosity, acid number, specific gravity and pH while the analysis of CNSL purification efforts included screening, management and use of ice cubes. The results obtained were yield (%) 29.76 ? 4.133, acid number (mg KOH / gr) 129.70 ? 10.927, specific gravity (g / ml) 1.086 ? 0.0009, viscosity (cps) 464.79 ? 42.959 and pH 6.13 ? 0.134. The way of purification efforts carried out by physical processes, use, use of ice cubes did not show significantly different results. It can be said that cashew nut shell oil can be used as raw material for pharmaceutical products from the amount of oil yield obtained and requested in the next research to find out more suitable methods for CNSL purification.
 F. Zafar, S. Khan, A. H. Mondal, E. Sharmin, Q. M. Rizwanul Haq, and N. Nishat. 2019. ?Application of FTIR-ATR spectroscopy to confirm the microwave assisted synthesis and curing of Cashew nut shell liquid derived nanostructured materials,? Spectrochim. Acta - Part A Mol. Biomol. Spectrosc., vol. 228, p. 117732, 2020, doi: 10.1016/j.saa.117732.
 Y. Ma et al. 2019. ?Highly branched and nontoxic plasticizers based on natural cashew shell oil by a facile and sustainable way,? J. Clean. Prod., vol. 252, p. 119597, 2020, doi: 10.1016/j.jclepro.119597.
 K. de P. Costa, B. M. de Viveiros, M. A. S. Schmidt Junior, P. A. Z. Suarez, and M. J. C. Rezende. 2019. ?Chemical transformations in technical cashew nut shell liquid and isolated mixture of cardanols, evaluation of the antioxidant activity and thermal stability of the products for use in pure biodiesel,? Fuel, vol. 235, no. July 2018, pp. 1010?1018, doi: 10.1016/j.fuel.2018.08.111.
 de S. L. Aracelli et al., 2015. ?Pharmacological properties of cashew (Anacardium occidentale),? African J. Biotechnol., vol. 15, no. 35, pp. 1855?1863, 2016, doi: 10.5897/ajb.15051.
 G. Okereke, O. Emmanuel, V. C. Ude, C. N. Ekweogu, V. O. Ikpeazu, and E. A. Ugbogu. 2020. ?Physicochemical characteristics, acute and subacute toxicity of cashew nut shell oil in Wistar rats,? Sci. African, vol. 8, p. e00391, 2020, doi: 10.1016/j.sciaf.e00391.
 L. B. Warsono, W. Atmaka, and B. S. Amanto.2013. ?Ekstraksi Cashew Nut Shell Liquid (CNSL) dari Kulit Biji Mete dengan Menggunakan Metode Pengepresan,? J. Teknosains Pangan, vol. 2, no. 2, pp. 84?92.
 A. Idah, I. Simeon, and M. Mohammed.2014. ?Extraction and Characterization of Cashew Nut (Anacardium Occidentale) Oil and Cashew Shell Liquid Oil,? Acad. Res. Int., vol. 5, no. 3, pp. 50?54, [Online]. Available: www.savap.org.pk%5Cnwww.journals.savap.org.pk.
 G. Pasaribu, G. Gusmailina, S. Komarayati, Z. Zulnely, and E. Dahlian. 2014. ?Analisis Senyawa Kimia Dryobalanops aromatica,? J. Penelit. Has. Hutan, vol. 32, no. 1, pp. 21?26, doi: 10.20886/jphh.2014.32.1.21-26.
 Sahaya, raden raya, Kusmajadi Suradi, Husmy Yurmiaty. 2011. Pengaruh penggunaan enzim papain sebagai bating agent pada proses penyamakan fur kelinci terhadap kualitas fisik. Student?s e-journal.