Aktivitas Penghambatan Radikal Bebas Difenil Pikril Hidrazil (DPPH) Ekstrak Daun Macaranga magna Turrill

DPPH Free Radical Scavenger Activity of Macaranga magna Turrill Leaves Extract

Authors

  • Minarti Minarti Pusat Riset Kimia, Badan Riset dan Inovasi Nasional Republik Indonesia, Kawasan PUSPIPTEK, Serpong, Tangerang Selatan, Indonesia 15314
  • Novita Ariani Pusat Riset Kimia, Badan Riset dan Inovasi Nasional Republik Indonesia, Kawasan PUSPIPTEK, Serpong, Tangerang Selatan, Indonesia 15314
  • Teni Ernawati Pusat Riset Kimia, Badan Riset dan Inovasi Nasional Republik Indonesia, Kawasan PUSPIPTEK, Serpong, Tangerang Selatan, Indonesia 15314
  • Akhmad Darmawan Pusat Riset Kimia, Badan Riset dan Inovasi Nasional Republik Indonesia, Kawasan PUSPIPTEK, Serpong, Tangerang Selatan, Indonesia 15314

DOI:

https://doi.org/10.25026/mpc.v14i1.568

Keywords:

Free radicals, antioxidants, Macaranga magna Turrill, 1,1-diphenyl-2-picrylhydrazyl (DPPH), total flavonoids, total phenol

Abstract

Degenerative disease is a disease that has a large number of sufferers in Indonesia and throughout the world, one of the causes of many sufferers of degenerative diseases such as diabetes and cancer is the large amount of exposure to free radicals in the body as a result of an unhealthy lifestyle. Antioxidant compounds are one of the chemical compounds that can be used and utilized to inhibit the oxidation process as a result of the presence of free radicals, so that the incidence of degenerative diseases can be suppressed. In this study, the active extraction and fractionation process from Macaranga magna Turrill leaves which have antioxidant activity and can be developed as a compound inhibiting the oxidation process of free radicals using the chromatographic method, as well as testing the antioxidant activity using the free radical inhibition method 1,1-diphenyl-2- picrylhydrazyl (DPPH). Preliminary test results of antioxidant activity on the methanol extract of Macaranga magna Turrill leaves are known that this plant has potential as an antioxidant with an IC50 value of 11.13 ?g/mL, this is also supported by the test results of total flavonoids 19.47 mg QE/g extract and total phenol 37, 77 mg GAE/g extract.

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Published

2021-12-31

How to Cite

Minarti, M., Ariani, N., Ernawati, T., & Darmawan, A. (2021). Aktivitas Penghambatan Radikal Bebas Difenil Pikril Hidrazil (DPPH) Ekstrak Daun Macaranga magna Turrill: DPPH Free Radical Scavenger Activity of Macaranga magna Turrill Leaves Extract. Proceeding of Mulawarman Pharmaceuticals Conferences, 14(1), 37–43. https://doi.org/10.25026/mpc.v14i1.568

Issue

Vol. 14 (2021): Proc. Mul. Pharm. Conf.

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Articles

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