Pengaruh Trietanolamin pada Basis Krim Minyak dalam Air yang Berbahan Dasar Asam Stearat dan Setil Alkohol
Effect of Triethanolamine on Oil-in-Water Cream Base Based on Stearic Acid and Cetyl Alcohol
DOI:
https://doi.org/10.25026/mpc.v14i1.573Keywords:
Cream, Trietanolamin, BaseAbstract
The cream is a semi-solid preparation with one or more ingredients dispersed in two types of emulsions, water-in-oil (W/O) and oil-in-water (O/W) type creams. Oil-in-water type cream has a high water content so that it can provide a hydration effect that can increase the penetration of the active substance. Triethanolamine in topical preparations is used as an emulsifier and alkalizing agent to form a homogeneous and stable cream. The purpose of this research was to determine the effect of triethanolamine on an oil-in-water cream base based on stearic acid and cetyl alcohol. Making the base is done by making preparations using four concentrations of triethanolamine 0.5% (F1), 1% (F2), 1.5% (F3), and 2% (F4). The cream base was then evaluated for its physical properties including organoleptic, homogeneity, pH, viscosity, spreadability, adhesion, and phase separation test. The results showed that in the organoleptic test cream bases were white, had a characteristic aroma with a semisolid form. The cream base has a homogeneity dispersion with an average pH between 6.53-7.29, viscosity between 3.5792396-3.8001904 (Pa.s), spreadability between 5.43-5.78 cm, and adhesion between 4.47-6.25 seconds. The cream base did not have phase separation and was stable in storage for 4 weeks at room temperature.
References
Allen, Loyd V, Nicholas G. P dan Howard C. Ansel. 2011. Ansel’s Pharmaceutical Dosage Forms and Drug Delivery System Ninth Edition. Wolters Kluwer: China.
Juwita, A. P., Yamlean, P. V., & Edy, H. J.2013. Formulasi krim ekstrak etanol daun lamun (Syringodium isoetifolium). Pharmacon, 2(2).
Nofriyanti dan Wildani.2019. Formulasi Krim Dari Ekstrak Air Daun Alpukat (Persea americana Mill.) Sebagai Sediaan Anti Jerawat. Jurnal Penelitian Farmasi Indonesia, 7(2), 51-56.
Ansel, H.C.. 1989. Pengantar Bentuk sediaan Farmasi. Edisi keempat.Universitas Indonesia : Jakarta.
Setyopratiwi, A., & Fitrianasari, P. N.2021. Formulasi Krim Antioksidan Berbahan Virgin Coconut Oil (VCO) dan Red Palm Oil (Rpo) dengan Variasi Konsentrasi Trietanolamin. BENCOOLEN JOURNAL OF PHARMACY, 1(1).
Rowe, R. C., P. J. Sheskey, dan M. E. Quinn. 2009. Handbook of Pharmaceutical Excipients. Sixth Edition. Pharmaceutical Press : London.
Lumentut, N., Edi, H. J., & Rumondor, E. M.2020. Formulasi dan Uji Stabilitas Fisik Sediaan Krim Ekstrak Etanol Kulit Buah Pisang Goroho (Musa acuminafe L.) Konsentrasi 12.5% Sebagai Tabir Surya. Jurnal MIPA, 9(2), 42-46.
Saryanti, D., Setiawan, I., & Safitri, R. A.2019. Optimasi Asam Stearat dan Tea pada Formula Sediaan Krim Ekstrak Kulit Pisang Kepok (Musa Paradisiaca L.). Jurnal Riset Kefarmasian Indonesia, 1(3), 225-237.
Anggraini, S., Mita, N., & Ibrahim, A. 2015. Formulasi dan Optimasi Basis Krim Tipe A/M dan Aktivitas Antioksidan Daun Cempedak (Artocarpus champeden Spreng). In Proceeding of Mulawarman Pharmaceuticals Conferences (Vol. 1, pp. 22-30).
Ekowati, D., & Hanifah, I. 2017. Potensi tongkol jagung (Zea mays L.) sebagai sunscreen dalam sediaan hand body lotion. Jurnal Ilmiah Manuntung, 2(2), 198-207.
Baskara, I., Suhendra, L., & Wrasiati, L. 2020. Pengaruh Suhu Pencampuran dan Lama Pengadukan terhadap Karakteristik Sediaan Krim. Jurnal Rekayasa dan Manajemen Agroindustri, 8(2), 200-209.
Lachman L, Lieberman H, Kanig J. 1994. Teori dan PraktekFarmasi Industri. Edisi ketiga. Universitas Indonesia: Jakarta.
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