Kajian Potensi Interaksi Obat pada Pasien COVID-19 di Rumah Sakit X Kota Samarinda

Study of Potential Drug Interactions in COVID-19 Patients at Hospital X Samarinda City

Authors

  • Shofia Siza Maulidia Laboratorium Penelitian dan Pengembangan Kefarmasian “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia
  • Febrina Mahmudah Laboratorium Penelitian dan Pengembangan Kefarmasian “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia
  • Yurika Sastyarina Laboratorium Penelitian dan Pengembangan Kefarmasian “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

DOI:

https://doi.org/10.25026/mpc.v14i1.587

Keywords:

COVID-19, polypharmacy, drug interactions

Abstract

Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease caused by a coronavirus known as SARS-CoV-2 and is currently a worldwide pandemic. Treatment management for COVID-19 patients is grouped based on the level of symptoms experienced by the patient. The use of large amounts of drugs (polypharmacy) in COVID-19 patients with moderate and severe symptoms can increase the possibility of drug interactions. This study aims to determine patient characteristics and the potential for drug interactions in COVID-19 patients at Hospital X Samarinda City. The data collection method was conducted retrospectively based on the medical records of COVID-19 patients hospitalized from March to December 2020. Data on potential drug interactions were analyzed using the Drugs.com application. The results showed that of the 30 patients with COVID-19, male-dominated (60%) and aged between 46 and 55 years (50%). Data on potential drug interactions showed that 28 out of 30 patients had the potential to experience drug interactions in the categories of severe (9,23%), moderate (74,62%), and mild (16,15%).

References

Yuliana. 2020. Corona virus disease (COVID-19): Sebuah Tinjauan Literatur. Wellness and Healthy Magazine. 2(1).

WHO (World Health Organization). 2021. WHO Coronavirus (COVID-19) [Internet]. URL: https://covid19.who.int/. Diakses pada 30 Mei 2021.

KPCPEN (Komite Penanganan COVID-19 dan Pemulihan Ekonomi Nasional). 2021. Data Sebaran COVID-19 di Indonesia. URL: https://covid19.go.id/. Diakses pada: 30 Mei 2021.

Merle L., Laroche M.L., Dantoine T., Charmes J.P. 2005. Predicting and Preventing Adverse Drug Reaction in The Very Old. Drugs and Aging. 22(5): 375-392.

Burhan E., Susanto A.D., Isbaniah F., Nasution S.A., Ginanjar E., Pitoyo C.W. 2020. Pedoman Tatalaksana COVID-19. Jakarta: PDPI, PERKI, PAPDI, PERDATIN, IDAI.

Wan Y., Shang J., Graham R., Baric R.S., and Li F. 2020. Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus. Journal of Virology. 94(7): 1-9. https://doi.org/10.1128/JVI.00127-20.

Shastri A., Wheat J., Agrawal S., Chaterjee N., Pradhan K., Goldfinger M., Kornblum N., Steidl U., Verma A., and Shastri J. 2020. Delayed Clearance of SARS-CoV2 in Male Compared to Female Patients: High ACE2 Expression in Testes Suggests Possible Existence of Gender-Specific Viral Reservoirs. MedRxiv. https://doi.org/10.1101/2020.04.16.20060566.

Gemmati D., Bramanti B., Serino M.L., Secchiero P., Zauli G., and Tisato V. 2020. COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-Chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males?. International Journal of Molecular Sciences. 21(10): 1-23. https://doi.org/10.3390/ijms21103474.

Liu J., Ji H., Zheng W., Wu X., Zhu J.J., Arnold A.P., and Sandberg K. 2010. Sex Differences in Renal Angiotensin Converting Enzyme 2 (ACE2) Activity are 17b-oestradiol-dependent and Sex Chromosome-independent. Biology of Sex Differences. 1(6): 1-11. https://doi.org/10.1186/2042-6410-1-6.

Begley S. 2020. Which Groups are Most at Risk from The Coronavirus? [Internet]. URL: https://www.scientificamerican.com/article/which-groups-are-most-at-risk-from-the-coronavirus/#. Diakses pada 15 November 2021.

Kamus Besar Bahasa Indonesia (KBBI). 2016. Pengertian Umur [Internet]. URL: https://kbbi.kemdikbud.go.id/entri/Umur. Diakses pada 15 November 2021.

Hikmawati I. dan Setiyabudi R. 2020. Hipertensi dan Diabetes Melitus sebagai Penyakit Penyerta Utama COVID-19 di Indonesia. Seminar Nasional Hasil Penenlitian dan Pengabdian pada Masyarakat V Tahun 2020 “Pengembangan Sumber Daya Menuju Masyarakat Madani Berkearifan Lokal”. 15 Maret 2021, Purwokerto, Indonesia. pp. 95-100. ISBN: 978-602-6697-66-0.

Leng J. and Goldstein D.R. 2010. Impact of Aging on Viral Infections. Microbes and Infection. 12(14-15): 1120-1124. https://doi.org/10.1016/j.micinf.2010.08.009.

Smits S.L., Lang A.d., Brand J.M.A.v.d., Leijten L.M., Ijcken W.F.v., Eijkemans M.J.C., Amerongen G.v., Kuiken T., Andeweg A.C., Osterhaus A.D.M.E., and Haagmans B.L. 2010. Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human Primates. PLoS Pathogens. 6(2): 1-15. https://doi.org/10.1371/journal.ppat.1000756.

Hohl C.H., Dankoff J., Colacone A., Afilalo M. 2001. Polypharmacy, Adverse Drug-Related Events, and Potential Adverse Drug Interactions in Elderly Patients Presenting to An Emergency Department. Ann Emerg Med. 38(6): 666–671.

Baxter K. 2008. Stockley’s Drug Interaction. 8th Edition. London: Pharmaceutical Press.

Hansten P.D. and Horn J.R. 2009. Drug Interactions and Update. 7th ed. WA Aplied Therapeutics Inc: Vancouver.

Herdaningsih S., Muhtadi A., Lestari K., dan Annisa N. 2016. Potensi Interaksi Obat-Obat pada Resep Polifarmasi: Studi Retrospektif pada Salah Satu Apotek di Kota Bandung. Jurnal Farmasi Klinik Indonesia. 5(4): 288–292. https://doi.org/10.15416/ijcp.2016.5.4.288.

Linden P.D.v.d., Sturkenboom M.C.J.M., Herings R.M.C., Leufkens H.M.G., Rowlands S., and Stricker B.H.Ch. 2003. Increased Risk of Achilles Tendon Rupture with Quinolone Antibacterial Use, Especially in Elderly Patients Taking Oral Corticosteroids. Arch. Intern. Med. 163: 1801-1807.

Lannini P.B. 2002. Cardiotoxicity of Macrolides, Ketolides, and Fluoroquinolones That Prolong The QTc Interval. Expert Opinion on Drug Safety. 1(2): 121-128.

Wyllie L.Y.P., Juurlink D.N., Kopp A., Shah B.R., Stukel T.A., Stumpo C., Dresser L., Low D.E., dan Mamdani M.M. 2006. Outpatient Gatifloxacin Therapy and Dysglycemia in Older Adults. New England Journal of Medicine. 354(13): 1352-1361.

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Published

2021-12-31

How to Cite

Maulidia, S. S., Mahmudah, F., & Sastyarina, Y. (2021). Kajian Potensi Interaksi Obat pada Pasien COVID-19 di Rumah Sakit X Kota Samarinda: Study of Potential Drug Interactions in COVID-19 Patients at Hospital X Samarinda City. Proceeding of Mulawarman Pharmaceuticals Conferences, 14(1), 295–301. https://doi.org/10.25026/mpc.v14i1.587

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