Karakteristik Granul Gastroretentive Mukoadhesif Amoksisilin dengan menggunakan Kitosan-Alginat, Na.CMC dan HPMC

Characteristics of Gastroretentive Mucoadhesive Granules Amoxicillin using Chitosan-Alginate, Na.CMC and HPMC

Authors

  • Siti Rofi’ah Febryani Laboratorium Penelitian dan Pengembangan Kefarmasian “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia
  • Sabaniah Indjar Gama Laboratorium Penelitian dan Pengembangan Kefarmasian “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia
  • Angga Cipta Narsa Laboratorium Penelitian dan Pengembangan Kefarmasian “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

DOI:

https://doi.org/10.25026/mpc.v14i1.588

Keywords:

Gastroretentive, Mucoadhesive, Granule, Amoxicilline, Characteristics, polymer

Abstract

Gastroretentive Drug Delivery System (GRDDS) is a slow-release preparation that can be bound to the surface of epithelial cells or gastric mucosa, while mucoadhesive is one of the mechanisms of action of the Gastroretentive Drug Delivery System (GRDDS), which is a drug delivery system in which the bio adhesive polymer is combined with the drug. designed to have a longer contact with the mucous membranes in the digestive tract. This study aims to see how the characteristics of the granules that are formulated in the form of mucoadhesive gastroretentive granules. The preparation method used was wet granulation using a mucoadhesive polymer, namely chitosan-alginate with the addition of HPMC and Sodium CMC. The results showed that the velocity test of the flow rate on the granule formula F1-F8 met the flow rate requirements, the results of the F9 velocity had a poor flow rate, while the results of the angle of repose measurement in the F1, F2 and F4 formulas had good flowability, which was below 30o, different with F3, F5, F6, F7, F8, and F9 which have a 30-40o angle of repose with good flowability. The results of the particle size distribution using the stratified sieve method showed that the formulas F1-F9 were mostly retained by a mesh number 20 sieve with a size of 426-850 m. The results of the test results of the gastroretentive mucoadhesive granule preparation of amoxicillin showed that the preparation met the requirements for making granules.

References

Sweetman, S.C. 2009. Martindale The Complete Drug Reference Thirty Sixth Edition Pharmaceutical Press : New York

Srifiana, Ari Widayanti dan Nopriyadi. 2019. Sodium Alginat as A Mucoadhesive Polymer to Adhesion Strength and Amoxicillin Mucoadhesion Granul Release. Jurnal Ilmu Kefarmasian Indonesia Volume 17 Nomor 1: 56-61. E-ISSN: 2614-6495

Hendrika, Yan, Julia Reveny, Sumaiyah Sumaiyah. 2018. Formulation and In Vitro Evaluation of Gastroretentive Floating Beads of Amoxicillin Using Pecting From Banana Peel (Musa Balbisiana Abb). Asian Journal Pharmaceutical and Clinical Research, Vol 11, Issue 3, 2018, 72-77. DOI: http://dx.doi.org/10.22159/ajpcr.2018.v11i4.23511.

Hamsinah, Jufri, Ermina Pakki. 2016. Formulasi dan Evaluasi Granul Gastroretentive Mukoadhesif Amoksisilin. JF FIK UINAM Vol.4 No.3 : 83-89.

Elisabeth, Victoria, Paulina V.Y. YamLean, Hamidah Sri Supriati. 2018. Formulasi sediaan granul dengan bahan pengikat pati kulit pisang goroho (Musa acuminafe L.) dan pengaruhnya pada sifat fisik granul. Pharmacon Jurnal Ilmiah Farmasi Vol. 7 No. 4. ISSN 2302-2493.

Aulton, M. E. 2002. Pharmaceutics the Science of Dosage Form Design Second Edition 530. ELBS Fonded by British Government.

Anonim. 2014. Farmakope Indonesia Edisi V. Departemen Kesehatan Republik Indonesia Hal. 1515-1516

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Published

2021-12-31

How to Cite

Febryani, S. R., Gama, S. I., & Narsa, A. C. (2021). Karakteristik Granul Gastroretentive Mukoadhesif Amoksisilin dengan menggunakan Kitosan-Alginat, Na.CMC dan HPMC: Characteristics of Gastroretentive Mucoadhesive Granules Amoxicillin using Chitosan-Alginate, Na.CMC and HPMC. Proceeding of Mulawarman Pharmaceuticals Conferences, 14(1), 302–306. https://doi.org/10.25026/mpc.v14i1.588

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