Sintesis 2’-Hidroksi-5’-Kloro-3,5-Dimetoksi-4-Hidroksikalkon
DOI:
https://doi.org/10.25026/mpc.v11i1.393Abstract
Chalcone are compounds that have 2 aromatic rings connected by 3 carbon atoms which are an ?, ? unsaturated carbonyl system that have various biological activities. 2'-hydroxy-5'-chloro-3,5-dimethoxy-4-hydroxicalcone was synthesized from 2'-hydroxy-5'-chloro acetophenone and syringaldehyde using a NaOH catalyst. This compound was purified using Column Chromatography by isocratic method using n-hexane:ethyl acetate (15:1) as eluent. This compound has a Rf 0.75 and 2.7% of yield.References
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[6] Mega Cahayani, Agung Rahmadani, Dewi Rahmawati, Rolan Rusli. 2018. Sintesis dan Uji Toksisitas Senyawa 2’,4’-Dikloro-4-Metoksikalkon. Jurnal Ilmiah Manuntung, 4(2), 84-88.
[2] Kamble, V.M., Hatnapure, G.D., Keche, A.P., Birajdar, S., Patil, S.G., Tale, R.H., Rodge, A.H., Turkar, S.S. and Gour, K. 2011. Sintesis and Biological Evaluation of a Novel Series of Methoxylated Chalcones as Antioxidant and Anti-microbial agents. Journal. Chemistry. Pharmceutical. Research. 3(6):639-648.
[3] Kurniati, Yuharmen, Adel Zamri. 2015. Toksisitas Senyawa Analog Kalkon 3’-Metoksiasetofenon Menggunakan Metode Brine Shrimp Lethality Test (BSLT). Jurnal Photon Vol. 6 No.1.
[4] Chen, Y.H., Wang, W.H., Lin, Z.Y and Chern, C.Y. 2013. Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model. Molecules. 18: 2052-2060.
[5] Lusrianti, Nur Balatif dan Adel Zamri. 2015. Sintesis dan Uji Toksisitas Senyawa Analog Kalkon dari 4’- Hidroksiasetofenon dengan Dimetoksibenzaldehid. Jurnal Photon Vol. 6 No.1.
[6] Mega Cahayani, Agung Rahmadani, Dewi Rahmawati, Rolan Rusli. 2018. Sintesis dan Uji Toksisitas Senyawa 2’,4’-Dikloro-4-Metoksikalkon. Jurnal Ilmiah Manuntung, 4(2), 84-88.
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Published
2020-02-28
How to Cite
Amanuddin, A., Arifian, H., Rahmadani, A., & Rusli, R. (2020). Sintesis 2’-Hidroksi-5’-Kloro-3,5-Dimetoksi-4-Hidroksikalkon. Proceeding of Mulawarman Pharmaceuticals Conferences, 11(1), 50–53. https://doi.org/10.25026/mpc.v11i1.393
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